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The Preston Robert Tisch Brain Tumor Center at Duke University Medical Center is one of the largest and most successful in the field. It has received the highest rating of "Outstanding" by a National Cancer Institute peer review group's evaluation of the Duke Comprehensive Cancer Center over the last ten years. Dedicated entirely to the treatment and cure of brain and spinal tumors in children and adults, we combine the resources of a leading research hub with a commitment to the best in patient care.

Scientific Advances at The Preston Robert Tisch Brain Tumor Center

Newly Discovered Gene Could Be a Prime Target in the Most Lethal Brain Cancer

Scientists at Duke University Medical Center and Johns Hopkins University have discovered mutations in two genes that could become therapeutic targets in malignant glioma, a dangerous class of brain tumors.

"The fact that the defective genes code for metabolic enzymes found only in malignant glioma, and not in normal tissue, could make the gene products therapeutic targets," says Hai Yan, MD, PhD, lead author, an assistant professor in the Duke Department of Pathology. The findings are published in the Feb. 19th issue of the New England Journal of Medicine.

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Hai Yan, MD, PhD