Clinical Trials for Adults

Clinical Trials for Adults

For more information about clinical trials at The Preston Robert Tisch Brain Tumor Center at Duke, call (919) 684-5301 or use our contact form.

Newly Diagnosed:

• Pro00027159:  H9H-MC-JBAI, Phase 1b/2a Study Combining LY2157299 with Standard Temozolomide-based Radiochemotherapy in Patients with Newly Diagnosed Malignant Glioma
• Pro00031192:  A Pilot Study of the Administration of Bone Marrow Derived Stem Cells (ALD-451) in WHO Grade IV Malignant Glioma
• Pro00033396:  An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF with Adjuvant Temozolomide/TMZ in Patients with Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma
• Pro00038098:  Phase II Trial of Bevacizumab, Radiation Therapy and Temodar followed by Bevacizumab and Temodar with Continuation of Bevacizumab Beyond Progression (BBP-Bevacizumab Beyond Progression)

Recurrent:

• A Phase I Clinical Trial for Recurrent Glioblastoma with Genetically Engineered Poliovirus (PVS-RIPO)
• Pro00006677:  Recurrent GBM Stem Cell Tumor Amplified RNA Immunotherapy Trial
• Pro00022491:  Phase II Study to Evaluate the Efficacy and Safety of AMG 102 and Avastin in Subjects with Recurrent Malignant Glioma
• Pro00028030:  A Phase I/II Single-Arm Open-Label Multicenter Study of VB-111 in Patients with Recurrent Glioblastoma Multiform 
• Pro00031169:  Dose-Finding and Safety Study of an Oncolytic Polio/Rhinovirus Recombinant Against recurrent Glioblastoma
• Pro00034085:  A Phase II Study of Rindopepimut/GM-CSF in Patients with Relapsed EGFRvIII-Positive Glioblastoma

Quality of Life/Supportive Care Studies

• Pro00019545:  Functional and Neurocognitive Profile of Patients Receiving Bevacizumab Containing Treatment Regimens for Glioblastoma Multiforme
• Pro00021750:  Clinical and Neurocognitive Outcomes in Long-term Survivors of Primary Glioblastoma Multiforme
• Pro00021808:  Functional and Neurocognitive Outcomes in Newly Diagnosed Glioblastoma Multiforme Patients Receiving a Bevacizumab-Containing Adjuvant Chemotherapy: A Prospective Cohort Study 
• Pro00027661: Effects of Low-Dose Naltrexone on Quality of Life in High-Grade Glioma Patients: A Placebo-Controlled, Double-Blind Randomized Trial