Overview

Recent discoveries in genetics and genomics hold great promise for the development of target-defined prevention- and chemotherapeutic-strategies for breast and ovarian cancer.  However, a coordinated, multi-disciplinary research effort is required to translate these new research discoveries into the next generation of therapeutic strategies.  To meet this challenge the Breast and Ovarian Cancer Program aims to 1) define early events in breast and ovarian carcinogenesis, 2) translate these advances into targeted therapeutic approaches for the prevention and treatment of breast and ovarian cancer, and 3) test these new therapies in investigator-initiated and multi-institutional clinical trials. The Program includes 29 full and 10 associate members from twelve basic and clinical departments within Duke University. Since its inception, the Program has successfully fostered scientific interactions between members of the Duke Comprehensive Cancer Center (DCCC) who have basic, translational, and clinical research interests in breast and ovarian cancer. Within the domain of the Program we developed five subprograms that draw from our translational research strength and ability to translate basic science discoveries to impact the early detection and treatment of breast and ovarian cancer: 1) Early detection strategies for breast and ovarian cancer;  2) Methylation imprinting and epigenetic dysregulation;  3) Basic breast and ovarian cancer biology and novel therapeutic targeting; 4) Genomics; and 5) Disparities for African American women. The diversity of interest and experimental approaches used by the members of the Breast and Ovarian Program represents an effective environment for fostering cross-fertilization of ideas aimed at understanding breast and ovarian cancer. In addition, the Program supports developmental projects, new faculty awards, and tissue procurement and banking. From 2004-2008, program members published 737 papers in peer-reviewed journals that bear directly on breast and/or ovarian cancer (increased 498).  Program members are highly collaborative. Of these publications, 46% are the result of inter-programmatic collaborations and 51% due to intra-program collaborations (increased from 6% and 10% respectively in 2003).

High-Impact Journal Publications

Below are recent publications in high-impact journals from Cancer Center members in this program. To see journal articles for a particular member, click on the researcher's name in the Membership section.

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Marks LB,Zeng J,Prosnitz LR. One to three versus four or more positive nodes and postmastectomy radiotherapy: time to end the debate., , (2075-7) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology No abstract available [More ...]

Seidman AD,Berry D,Cirrincione C,Harris L,Muss H,Marcom PK,Gipson G,Burstein H,Lake D,Shapiro CL,Ungaro P,Norton L,Winer E,Hudis C. Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of Cancer and Leukemia Group B protocol 9840., , (1642-9) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology Abstract [More ...]

Jirtle RL. Randy L. Jirtle, PhD: epigenetics a window on gene dysregulation, disease. Interview by Bridget M. Kuehn., , (1249-50) - JAMA : the journal of the American Medical Association No abstract available [More ...]

Skala MC,Riching KM,Gendron-Fitzpatrick A,Eickhoff J,Eliceiri KW,White JG,Ramanujam N. In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia., . Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Berchuck A. Chemotherapy administration for ovarian cancer by gynecologic oncologists and medical oncologists., , (3552) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology No abstract available [More ...]

Dolinoy DC,Huang D,Jirtle RL. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development., , (13056-61) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Demark-Wahnefried W,Clipp EC,Lipkus IM,Lobach D,Snyder DC,Sloane R,Peterson B,Macri JM,Rock CL,McBride CM,Kraus WE. Main outcomes of the FRESH START trial: a sequentially tailored, diet and exercise mailed print intervention among breast and prostate cancer survivors., , (2709-18) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology Abstract [More ...]

Mikkelsen TS,Wakefield MJ,Aken B,Amemiya CT,Chang JL,Duke S,Garber M,Gentles AJ,Goodstadt L,Heger A,Jurka J,Kamal M,Mauceli E,Searle SM,Sharpe T,Baker ML,Batzer MA,Benos PV,Belov K,Clamp M,Cook A,Cuff J,Das R,Davidow L,Deakin JE,Fazzari MJ,Glass JL,Grabherr M,Greally JM,Gu W,Hore TA,Huttley GA,Kleber M,Jirtle RL,Koina E,Lee JT,Mahony S,Marra MA,Miller RD,Nicholls RD,Oda M,Papenfuss AT,Parra ZE,Pollock DD,Ray DA,Schein JE,Speed TP,Thompson K,VandeBerg JL,Wade CM,Walker JA,Waters PD,Webber C,Weidman JR,Xie X,Zody MC,Baldwin J,Abdouelleil A,Abdulkadir J,Abebe A,Abera B,Abreu J,Acer SC,Aftuck L,Alexander A,An P,Anderson E,Anderson S,Arachi H,Azer M,Bachantsang P,Barry A,Bayul T,Berlin A,Bessette D,Bloom T,Bloom T,Boguslavskiy L,Bonnet C,Boukhgalter B,Bourzgui I,Brown A,Cahill P,Channer S,Cheshatsang Y,Chuda L,Citroen M,Collymore A,Cooke P,Costello M,D'Aco K,Daza R,De Haan G,DeGray S,DeMaso C,Dhargay N,Dooley K,Dooley E,Doricent M,Dorje P,Dorjee K,Dupes A,Elong R,Falk J,Farina A,Faro S,Ferguson D,Fisher S,Foley CD,Franke A,Friedrich D,Gadbois L,Gearin G,Gearin CR,Giannoukos G,Goode T,Graham J,Grandbois E,Grewal S,Gyaltsen K,Hafez N,Hagos B,Hall J,Henson C,Hollinger A,Honan T,Huard MD,Hughes L,Hurhula B,Husby ME,Kamat A,Kanga B,Kashin S,Khazanovich D,Kisner P,Lance K,Lara M,Lee W,Lennon N,Letendre F,LeVine R,Lipovsky A,Liu X,Liu J,Liu S,Lokyitsang T,Lokyitsang Y,Lubonja R,Lui A,MacDonald P,Magnisalis V,Maru K,Matthews C,McCusker W,McDonough S,Mehta T,Meldrim J,Meneus L,Mihai O,Mihalev A,Mihova T,Mittelman R,Mlenga V,Montmayeur A,Mulrain L,Navidi A,Naylor J,Negash T,Nguyen T,Nguyen N,Nicol R,Norbu C,Norbu N,Novod N,O'Neill B,Osman S,Markiewicz E,Oyono OL,Patti C,Phunkhang P,Pierre F,Priest M,Raghuraman S,Rege F,Reyes R,Rise C,Rogov P,Ross K,Ryan E,Settipalli S,Shea T,Sherpa N,Shi L,Shih D,Sparrow T,Spaulding J,Stalker J,Stange-Thomann N,Stavropoulos S,Stone C,Strader C,Tesfaye S,Thomson T,Thoulutsang Y,Thoulutsang D,Topham K,Topping I,Tsamla T,Vassiliev H,Vo A,Wangchuk T,Wangdi T,Weiand M,Wilkinson J,Wilson A,Yadav S,Young G,Yu Q,Zembek L,Zhong D,Zimmer A,Zwirko Z,Jaffe DB,Alvarez P,Brockman W,Butler J,Chin C,Gnerre S,MacCallum I,Graves JA,Ponting CP,Breen M,Samollow PB,Lander ES,Lindblad-Toh K. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences., , (167-77) - Nature Abstract [More ...]

Seewaldt VL,Scott V. Images in clinical medicine. Rapid progression of basal-type breast cancer., , (e12) - The New England journal of medicine No abstract available [More ...]

Smiley RD,Collins TR,Hammes GG,Hsieh TS. Single-molecule measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase II., . Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

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Click here for these and other high-impact publications in this research program.