Breast and Ovarian Oncology Research Program

Overview

Recent discoveries in genetics and genomics hold great promise for the development of target-defined prevention- and chemotherapeutic-strategies for breast and ovarian cancer. However, a coordinated, multi-disciplinary research effort is required to translate these new research discoveries into the next generation of therapeutic strategies. To meet this challenge, the Breast and Ovarian Oncology Program of the Duke Comprehensive Cancer Center (DCCC) has worked to 1) define early events in breast and ovarian carcinogenesis, 2) translate these advances into targeted therapeutic approaches for the prevention and treatment of breast and ovarian cancer, and 3) test these new therapies in investigator-initiated and multi-institutional clinical trials.

High-Impact Journal Publications

Below are recent publications in high-impact journals from Cancer Center members in this program. To see journal articles for a particular member, click on the researcher's name in the Membership section.

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Sathornsumetee S,Cao Y,Marcello JE,Herndon JE 2nd,McLendon RE,Desjardins A,Friedman HS,Dewhirst MW,Vredenburgh JJ,Rich JN. Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan., Jan 10,2008, (271-8) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology Abstract [More ...]

Johnson CE,Huang YY,Parrish AB,Smith MI,Vaughn AE,Zhang Q,Wright KM,Van Dyke T,Wechsler-Reya RJ,Kornbluth S,Deshmukh M. Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues., Dec 18,2007. Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Nevins JR. New breast cancer genes-discovery at the intersection of complex data sets., Dec 01,2007, (497-9) - Cancer cell Abstract [More ...]

Lyman GH,Khorana AA,Falanga A,Clarke-Pearson D,Flowers C,Jahanzeb M,Kakkar A,Kuderer NM,Levine MN,Liebman H,Mendelson D,Raskob G,Somerfield MR,Thodiyil P,Trent D,Francis CW. American Society of Clinical Oncology Guideline: Recommendations for Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer., Oct 29,2007. Journal of clinical oncology : official journal of the American Society of Clinical Oncology Abstract [More ...]

Zandy NL,Playford M,Pendergast AM. Abl tyrosine kinases regulate cell cell adhesion through Rho GTPases., Oct 26,2007. Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Hsu DS,Balakumaran BS,Acharya CR,Vlahovic V,Walters KS,Garman K,Anders C,Riedel RF,Lancaster J,Harpole D,Dressman HK,Nevins JR,Febbo PG,Potti A. Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer., Oct 01,2007, (4350-7) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology Abstract [More ...]

Wu JQ,Hansen DV,Guo Y,Wang MZ,Tang W,Freel CD,Tung JJ,Jackson PK,Kornbluth S. Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A., Sep 19,2007. Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Berchuck A. Chemotherapy administration for ovarian cancer by gynecologic oncologists and medical oncologists., Aug 10,2007, (3552) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology No abstract available [More ...]

Giangrande PH,Zhang J,Tanner A,Eckhart AD,Rempel RE,Andrechek ER,Layzer JM,Keys JR,Hagen PO,Nevins JR,Koch WJ,Sullenger BA. Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia., Aug 07,2007, (12988-93) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Kuderer NM,Dale DC,Crawford J,Lyman GH. Impact of primary prophylaxis with granulocyte colony-stimulating factor on febrile neutropenia and mortality in adult cancer patients receiving chemotherapy: a systematic review., Jul 20,2007, (3158-67) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology Abstract [More ...]

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Click here for these and other high-impact publications in this research program.