Overview

The goal of the Program in Cell Regulation and Transmembrane Signaling is to foster scientific interactions between members of the Duke Comprehensive Cancer Center (DCCC) who have interest in understanding the biology involved in regulating cell proliferation and death.  The Program continues to attract individuals interested in aspects of cell signaling. Currently, the Program includes 36 members from 9 different basic and clinical departments.  To foster an outstanding forum for scientific discourse and collaboration, the Program remains organized into one of four interest groups that include 1) transmembrane signaling; 2) intracellular signaling; 3) cell proliferation and death; and 4) signaling and disease. The program sponsors three distinct educational activities, the University-wide weekly seminar series “The Signal Transduction Colloquium” (STQ), the most attended series on campus; a graduate course in Cellular Signaling, taken by the majority of biomedical graduate students; and an Annual Offsite Retreat. The last two years’ retreats each featured more than 20 platform and 100 poster presentations by members, students and fellows.  Speakers for the STQ selected by a panel of Program members come primarily from outside the Duke University Medical Center to represent the broad interests of the membership. Each colloquium speaker meets with interested members of the Program and lunches with students in the Molecular Cancer Biology Graduate Program immediately after completion of the seminar. The diversity of experimental approaches used by the members of this Program represents an effective asset for promoting cross-fertilization of ideas aimed at understanding cell growth and regulation.  During the last grant period, members of the Program have published 800 papers in primary peer-reviewed journals of which 732 or 90% bear directly on cancer-related problems.  Finally nearly 15% of the cancer-related publications (98) are the result of intra-programmatic or inter-programmatic collaboration among DCCC members. At the present time, there are 36 program investigators. 

High-Impact Journal Publications

Below are recent publications in high-impact journals from Cancer Center members in this program. To see journal articles for a particular member, click on the researcher's name in the Membership section.

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Kurokawa M,Kornbluth S. Caspases and kinases in a death grip., , (838-54) - Cell Abstract [More ...]

Song J,Bishop BL,Li G,Grady R,Stapleton A,Abraham SN. TLR4-mediated expulsion of bacteria from infected bladder epithelial cells., . Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Heitman J. Microbial genetics: Love the one you're with., , (807-8) - Nature No abstract available [More ...]

Joseph JD,Wittmann BM,Dwyer MA,Cui H,Dye DA,McDonnell DP,Norris JD. Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists., , (12178-83) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Vergara SV,Thiele DJ. Ironing out a midlife crisis., , (1179-81) - Cell Abstract [More ...]

Zidar DA,Violin JD,Whalen EJ,Lefkowitz RJ. Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands., , (9649-54) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Giangreco A,Arwert EN,Rosewell IR,Snyder J,Watt FM,Stripp BR. Stem cells are dispensable for lung homeostasis but restore airways after injury., , (9286-91) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Butler G,Rasmussen MD,Lin MF,Santos MA,Sakthikumar S,Munro CA,Rheinbay E,Grabherr M,Forche A,Reedy JL,Agrafioti I,Arnaud MB,Bates S,Brown AJ,Brunke S,Costanzo MC,Fitzpatrick DA,de Groot PW,Harris D,Hoyer LL,Hube B,Klis FM,Kodira C,Lennard N,Logue ME,Martin R,Neiman AM,Nikolaou E,Quail MA,Quinn J,Santos MC,Schmitzberger FF,Sherlock G,Shah P,Silverstein KA,Skrzypek MS,Soll D,Staggs R,Stansfield I,Stumpf MP,Sudbery PE,Srikantha T,Zeng Q,Berman J,Berriman M,Heitman J,Gow NA,Lorenz MC,Birren BW,Kellis M,Cuomo CA. Evolution of pathogenicity and sexual reproduction in eight Candida genomes., , (657-62) - Nature Abstract [More ...]

Virshup DM,Forger DB. Keeping the beat in the rising heat., , (602-4) - Cell Abstract [More ...]

Caron MG,Wightman RM. "To learn, you must pay attention." Molecular insights into teachers' wisdom., , (7267-8) - Proceedings of the National Academy of Sciences of the United States of America No abstract available [More ...]

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Click here for these and other high-impact publications in this research program.