Cancer Genetics and Genomics Research Program
High-Impact Journal Publications
Anguiano A,Tuchman SA,Acharya C,Salter K,Gasparetto C,Zhan F,Dhodapkar M,Nevins J,Barlogie B,Shaughnessy JD Jr,Potti A. Gene expression profiles of tumor biology provide a novel approach to prognosis and may guide the selection of therapeutic targets in multiple myeloma., , (4197-203) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology
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Ellis MJ,Gao F,Dehdashti F,Jeffe DB,Marcom PK,Carey LA,Dickler MN,Silverman P,Fleming GF,Kommareddy A,Jamalabadi-Majidi S,Crowder R,Siegel BA. Lower-dose vs high-dose oral estradiol therapy of hormone receptor-positive, aromatase inhibitor-resistant advanced breast cancer: a phase 2 randomized study., , (774-80) - JAMA : the journal of the American Medical Association
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Febbo PG. Epigenetic events highlight the challenge of validating prognostic biomarkers during the clinical and biologic evolution of prostate cancer., , (3088-90) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology No abstract available [
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Heintzman ND,Hon GC,Hawkins RD,Kheradpour P,Stark A,Harp LF,Ye Z,Lee LK,Stuart RK,Ching CW,Ching KA,Antosiewicz-Bourget JE,Liu H,Zhang X,Green RD,Lobanenkov VV,Stewart R,Thomson JA,Crawford GE,Kellis M,Ren B. Histone modifications at human enhancers reflect global cell-type-specific gene expression., . Nature
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Mendiratta P,Mostaghel E,Guinney J,Tewari AK,Porrello A,Barry WT,Nelson PS,Febbo PG. Genomic Strategy for Targeting Therapy in Castration-Resistant Prostate Cancer., . Journal of clinical oncology : official journal of the American Society of Clinical Oncology
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Hsu DS,Acharya CR,Balakumaran BS,Riedel RF,Kim MK,Stevenson M,Tuchman S,Mukherjee S,Barry W,Dressman HK,Nevins JR,Powers S,Mu D,Potti A. Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer., . Proceedings of the National Academy of Sciences of the United States of America
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Read TA,Fogarty MP,Markant SL,McLendon RE,Wei Z,Ellison DW,Febbo PG,Wechsler-Reya RJ. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma., , (135-47) - Cancer cell
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Whitehead KJ,Chan AC,Navankasattusas S,Koh W,London NR,Ling J,Mayo AH,Drakos SG,Jones CA,Zhu W,Marchuk DA,Davis GE,Li DY. The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases., , (177-84) - Nature medicine
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Garman KS,Acharya CR,Edelman E,Grade M,Gaedcke J,Sud S,Barry W,Diehl AM,Provenzale D,Ginsburg GS,Ghadimi BM,Ried T,Nevins JR,Mukherjee S,Hsu D,Potti A. A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities., , (19432-7) - Proceedings of the National Academy of Sciences of the United States of America
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Califf RM,Ginsburg GS. Organizational improvements to enhance modern clinical epidemiology., , (2300-2) - JAMA : the journal of the American Medical Association No abstract available [
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Niedre MJ,de Kleine RH,Aikawa E,Kirsch DG,Weissleder R,Ntziachristos V. Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo., . Proceedings of the National Academy of Sciences of the United States of America
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Strauss GM,Herndon JE 2nd,Maddaus MA,Johnstone DW,Johnson EA,Harpole DH,Gillenwater HH,Watson DM,Sugarbaker DJ,Schilsky RL,Vokes EE,Green MR. Adjuvant paclitaxel plus carboplatin compared with observation in stage IB non-small-cell lung cancer: CALGB 9633 with the Cancer and Leukemia Group B, Radiation Therapy Oncology Group, and North Central Cancer Treatment Group Study Groups., , (5043-51) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology
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Lenz G,Wright GW,Emre NC,Kohlhammer H,Dave SS,Davis RE,Carty S,Lam LT,Shaffer AL,Xiao W,Powell J,Rosenwald A,Ott G,Muller-Hermelink HK,Gascoyne RD,Connors JM,Campo E,Jaffe ES,Delabie J,Smeland EB,Rimsza LM,Fisher RI,Weisenburger DD,Chan WC,Staudt LM. Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways., , (13520-5) - Proceedings of the National Academy of Sciences of the United States of America
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Shaffer AL,Emre NC,Lamy L,Ngo VN,Wright G,Xiao W,Powell J,Dave S,Yu X,Zhao H,Zeng Y,Chen B,Epstein J,Staudt LM. IRF4 addiction in multiple myeloma., , (226-31) - Nature
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Anders CK,Hsu DS,Broadwater G,Acharya CR,Foekens JA,Zhang Y,Wang Y,Marcom PK,Marks JR,Febbo PG,Nevins JR,Potti A,Blackwell KL. Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression., , (3324-30) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology
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Orlando DA,Lin CY,Bernard A,Wang JY,Socolar JE,Iversen ES,Hartemink AJ,Haase SB. Global control of cell-cycle transcription by coupled CDK and network oscillators., , (944-7) - Nature
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Haga SB,Willard HF. Letting the genome out of the bottle., , (2184; author reply 2185) - The New England journal of medicine No abstract available [
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Lin NU,Carey LA,Liu MC,Younger J,Come SE,Ewend M,Harris GJ,Bullitt E,Van den Abbeele AD,Henson JW,Li X,Gelman R,Burstein HJ,Kasparian E,Kirsch DG,Crawford A,Hochberg F,Winer EP. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer., , (1993-9) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology
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Acharya CR,Hsu DS,Anders CK,Anguiano A,Salter KH,Walters KS,Redman RC,Tuchman SA,Moylan CA,Mukherjee S,Barry WT,Dressman HK,Ginsburg GS,Marcom KP,Garman KS,Lyman GH,Nevins JR,Potti A. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer., , (1574-87) - JAMA : the journal of the American Medical Association
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Seidman AD,Berry D,Cirrincione C,Harris L,Muss H,Marcom PK,Gipson G,Burstein H,Lake D,Shapiro CL,Ungaro P,Norton L,Winer E,Hudis C. Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of Cancer and Leukemia Group B protocol 9840., , (1642-9) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology
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Ginsburg GS,Burke TW,Febbo P. Centralized biorepositories for genetic and genomic research., , (1359-61) - JAMA : the journal of the American Medical Association No abstract available [
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Boyle AP,Davis S,Shulha HP,Meltzer P,Margulies EH,Weng Z,Furey TS,Crawford GE. High-resolution mapping and characterization of open chromatin across the genome., , (311-22) - Cell
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Gottwein E,Mukherjee N,Sachse C,Frenzel C,Majoros WH,Chi JT,Braich R,Manoharan M,Soutschek J,Ohler U,Cullen BR. A viral microRNA functions as an orthologue of cellular miR-155., , (1096-9) - Nature
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Nevins JR. New breast cancer genes-discovery at the intersection of complex data sets., , (497-9) - Cancer cell
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Iversen ES Jr,Katki HA,Chen S,Berry DA,Parmigiani G. Limited family structure and breast cancer risk., , (2007; author reply 2007-8) - JAMA : the journal of the American Medical Association No abstract available [
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Willard HF. Honest Jim talks manners., , (787) - Nature No abstract available [
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Hsu DS,Balakumaran BS,Acharya CR,Vlahovic V,Walters KS,Garman K,Anders C,Riedel RF,Lancaster J,Harpole D,Dressman HK,Nevins JR,Febbo PG,Potti A. Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer., , (4350-7) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology
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Berchuck A. Chemotherapy administration for ovarian cancer by gynecologic oncologists and medical oncologists., , (3552) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology No abstract available [
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Giangrande PH,Zhang J,Tanner A,Eckhart AD,Rempel RE,Andrechek ER,Layzer JM,Keys JR,Hagen PO,Nevins JR,Koch WJ,Sullenger BA. Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia., , (12988-93) - Proceedings of the National Academy of Sciences of the United States of America
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Cuadros M,Dave SS,Jaffe ES,Honrado E,Milne R,Alves J,Rodríguez J,Zajac M,Benitez J,Staudt LM,Martinez-Delgado B. Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas., , (3321-9) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology
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Kirsch DG,Dinulescu DM,Miller JB,Grimm J,Santiago PM,Young NP,Nielsen GP,Quade BJ,Chaber CJ,Schultz CP,Takeuchi O,Bronson RT,Crowley D,Korsmeyer SJ,Yoon SS,Hornicek FJ,Weissleder R,Jacks T. A spatially and temporally restricted mouse model of soft tissue sarcoma., , (992-7) - Nature medicine
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Annunziata CM,Davis RE,Demchenko Y,Bellamy W,Gabrea A,Zhan F,Lenz G,Hanamura I,Wright G,Xiao W,Dave S,Hurt EM,Tan B,Zhao H,Stephens O,Santra M,Williams DR,Dang L,Barlogie B,Shaughnessy JD Jr,Kuehl WM,Staudt LM. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma., , (115-30) - Cancer cell
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Birney E,Stamatoyannopoulos JA,Dutta A,Guigó R,Gingeras TR,Margulies EH,Weng Z,Snyder M,Dermitzakis ET,Thurman RE,Kuehn MS,Taylor CM,Neph S,Koch CM,Asthana S,Malhotra A,Adzhubei I,Greenbaum JA,Andrews RM,Flicek P,Boyle PJ,Cao H,Carter NP,Clelland GK,Davis S,Day N,Dhami P,Dillon SC,Dorschner MO,Fiegler H,Giresi PG,Goldy J,Hawrylycz M,Haydock A,Humbert R,James KD,Johnson BE,Johnson EM,Frum TT,Rosenzweig ER,Karnani N,Lee K,Lefebvre GC,Navas PA,Neri F,Parker SC,Sabo PJ,Sandstrom R,Shafer A,Vetrie D,Weaver M,Wilcox S,Yu M,Collins FS,Dekker J,Lieb JD,Tullius TD,Crawford GE,Sunyaev S,Noble WS,Dunham I,Denoeud F,Reymond A,Kapranov P,Rozowsky J,Zheng D,Castelo R,Frankish A,Harrow J,Ghosh S,Sandelin A,Hofacker IL,Baertsch R,Keefe D,Dike S,Cheng J,Hirsch HA,Sekinger EA,Lagarde J,Abril JF,Shahab A,Flamm C,Fried C,Hackermüller J,Hertel J,Lindemeyer M,Missal K,Tanzer A,Washietl S,Korbel J,Emanuelsson O,Pedersen JS,Holroyd N,Taylor R,Swarbreck D,Matthews N,Dickson MC,Thomas DJ,Weirauch MT,Gilbert J,Drenkow J,Bell I,Zhao X,Srinivasan KG,Sung WK,Ooi HS,Chiu KP,Foissac S,Alioto T,Brent M,Pachter L,Tress ML,Valencia A,Choo SW,Choo CY,Ucla C,Manzano C,Wyss C,Cheung E,Clark TG,Brown JB,Ganesh M,Patel S,Tammana H,Chrast J,Henrichsen CN,Kai C,Kawai J,Nagalakshmi U,Wu J,Lian Z,Lian J,Newburger P,Zhang X,Bickel P,Mattick JS,Carninci P,Hayashizaki Y,Weissman S,Hubbard T,Myers RM,Rogers J,Stadler PF,Lowe TM,Wei CL,Ruan Y,Struhl K,Gerstein M,Antonarakis SE,Fu Y,Green ED,Karaöz U,Siepel A,Taylor J,Liefer LA,Wetterstrand KA,Good PJ,Feingold EA,Guyer MS,Cooper GM,Asimenos G,Dewey CN,Hou M,Nikolaev S,Montoya-Burgos JI,Löytynoja A,Whelan S,Pardi F,Massingham T,Huang H,Zhang NR,Holmes I,Mullikin JC,Ureta-Vidal A,Paten B,Seringhaus M,Church D,Rosenbloom K,Kent WJ,Stone EA,Batzoglou S,Goldman N,Hardison RC,Haussler D,Miller W,Sidow A,Trinklein ND,Zhang ZD,Barrera L,Stuart R,King DC,Ameur A,Enroth S,Bieda MC,Kim J,Bhinge AA,Jiang N,Liu J,Yao F,Vega VB,Lee CW,Ng P,Shahab A,Yang A,Moqtaderi Z,Zhu Z,Xu X,Squazzo S,Oberley MJ,Inman D,Singer MA,Richmond TA,Munn KJ,Rada-Iglesias A,Wallerman O,Komorowski J,Fowler JC,Couttet P,Bruce AW,Dovey OM,Ellis PD,Langford CF,Nix DA,Euskirchen G,Hartman S,Urban AE,Kraus P,Van Calcar S,Heintzman N,Kim TH,Wang K,Qu C,Hon G,Luna R,Glass CK,Rosenfeld MG,Aldred SF,Cooper SJ,Halees A,Lin JM,Shulha HP,Zhang X,Xu M,Haidar JN,Yu Y,Ruan Y,Iyer VR,Green RD,Wadelius C,Farnham PJ,Ren B,Harte RA,Hinrichs AS,Trumbower H,Clawson H,Hillman-Jackson J,Zweig AS,Smith K,Thakkapallayil A,Barber G,Kuhn RM,Karolchik D,Armengol L,Bird CP,de Bakker PI,Kern AD,Lopez-Bigas N,Martin JD,Stranger BE,Woodroffe A,Davydov E,Dimas A,Eyras E,Hallgrímsdóttir IB,Huppert J,Zody MC,Abecasis GR,Estivill X,Bouffard GG,Guan X,Hansen NF,Idol JR,Maduro VV,Maskeri B,McDowell JC,Park M,Thomas PJ,Young AC,Blakesley RW,Muzny DM,Sodergren E,Wheeler DA,Worley KC,Jiang H,Weinstock GM,Gibbs RA,Graves T,Fulton R,Mardis ER,Wilson RK,Clamp M,Cuff J,Gnerre S,Jaffe DB,Chang JL,Lindblad-Toh K,Lander ES,Koriabine M,Nefedov M,Osoegawa K,Yoshinaga Y,Zhu B,de Jong PJ. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project., , (799-816) - Nature
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Vokes EE,Herndon JE 2nd,Kelley MJ,Cicchetti MG,Ramnath N,Neill H,Atkins JN,Watson DM,Akerley W,Green MR. Induction Chemotherapy Followed by Chemoradiotherapy Compared With Chemoradiotherapy Alone for Regionally Advanced Unresectable Stage III Non-Small-Cell Lung Cancer: Cancer and Leukemia Group B., . Journal of clinical oncology : official journal of the American Society of Clinical Oncology
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Dressman HK,Berchuck A,Chan G,Zhai J,Bild A,Sayer R,Cragun J,Clarke J,Whitaker RS,Li L,Gray J,Marks J,Ginsburg GS,Potti A,West M,Nevins JR,Lancaster JM. An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer., , (517-25) - Journal of clinical oncology : official journal of the American Society of Clinical Oncology
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Ventura A,Kirsch DG,McLaughlin ME,Tuveson DA,Grimm J,Lintault L,Newman J,Reczek EE,Weissleder R,Jacks T. Restoration of p53 function leads to tumour regression in vivo., , (661-5) - Nature
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