Overview

The Cancer Biology Program was developed in recognition that cancer is a disease that extends beyond the cancer cell itself, with the goal of promoting studies on the molecular mechanisms of cancer in the context of the whole body.  Because of the complex nature of cancer when viewed as a disease of the body, the Cancer Biology Program unites and supports current and future scientists of different disciplines.  To achieve this goal, the Cancer Biology program is partitioned into three overlapping focus groups 1) Molecular Tumorigenesis: overseen by Drs. Gerry Blobe, Chris Counter, and Ann Marie Pendergast and is focused on studying the molecular mechanisms of tumorigenesis in vivo.  2) Cancer Stem Cell Biology: overseen by Drs. Brigid Hogan and Tannishtha Reya and is focused on understanding the role of stem cells in cancer, as well as how to exploit their capacity to maintain healthy tissues and to replace cells lost by disease or injury.  3) Cancer Immunobiology: overseen by Drs. Timothy Clay and H. Kim Lyerly and is focused on studying immunological aspects of cancer biology and treatment.  Together these three focus groups encompass the major disciplines of in vivo cancer biology. The Program includes 37 members from 10 basic and clinical departments within Duke University. From 2004-2008, program members published 625 papers in peer-reviewed journals cited in PubMed. Of these publications, 10% are the result of intra-programmatic collaborations and 19% due to inter-programmatic collaborations.

High-Impact Journal Publications

Below are recent publications in high-impact journals from Cancer Center members in this program. To see journal articles for a particular member, click on the researcher's name in the Membership section.

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Rock JR,Onaitis MW,Rawlins EL,Lu Y,Clark CP,Xue Y,Randell SH,Hogan BL. Basal cells as stem cells of the mouse trachea and human airway epithelium., , (12771-5) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Giangreco A,Arwert EN,Rosewell IR,Snyder J,Watt FM,Stripp BR. Stem cells are dispensable for lung homeostasis but restore airways after injury., , (9286-91) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Ma Q,Cavallin LE,Yan B,Zhu S,Duran EM,Wang H,Hale LP,Dong C,Cesarman E,Mesri EA,Goldschmidt-Clermont PJ. Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma., , (8683-8) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Mythreye K,Blobe GC. The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42., , (8221-6) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Lima B,Lam GK,Xie L,Diesen DL,Villamizar N,Nienaber J,Messina E,Bowles D,Kontos CD,Hare JM,Stamler JS,Rockman HA. Endogenous S-nitrosothiols protect against myocardial injury., . Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Zhao C,Chen A,Jamieson CH,Fereshteh M,Abrahamsson A,Blum J,Kwon HY,Kim J,Chute JP,Rizzieri D,Munchhof M,VanArsdale T,Beachy PA,Reya T. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia., . Nature Abstract [More ...]

Que J,Wilm B,Hasegawa H,Wang F,Bader D,Hogan BL. Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development., , (16626-30) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Bekyarova TI,Reedy MC,Baumann BA,Tregear RT,Ward A,Krzic U,Prince KM,Perz-Edwards RJ,Reconditi M,Gore D,Irving TC,Reedy MK. Reverse actin sliding triggers strong myosin binding that moves tropomyosin., , (10372-7) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Coveney D,Cool J,Oliver T,Capel B. Four-dimensional analysis of vascularization during primary development of an organ, the gonad., , (7212-7) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Stamler JS,Sun QA,Hess DT. A SNO storm in skeletal muscle., , (33-5) - Cell Abstract [More ...]

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Click here for these and other high-impact publications in this research program.