- Author
- Marengo MS,Garcia-Blanco MA
- Title
- Shedding UV light on alternative splicing.
- Publication Date
- 5/15/2009
- Pages
- 600-2
- Journal Name
- Cell
- Abstract
- After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.
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