High-Impact Journal Publications

Gao W,Liu W,Mackay JA,Zalutsky MR,Toone EJ,Chilkoti A. In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics., . Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Hammes GG,Chang YC,Oas TG. Conformational selection or induced fit: a flux description of reaction mechanism., , (13737-41) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Hamburger JB,Hoertz AJ,Lee A,Senturia RJ,McCafferty DG,Loll PJ. A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface., , (13759-64) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Zidar DA,Violin JD,Whalen EJ,Lefkowitz RJ. Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands., , (9649-54) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Erickson HP. Modeling the physics of FtsZ assembly and force generation., , (9238-43) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Shenoy SK,Modi AS,Shukla AK,Xiao K,Berthouze M,Ahn S,Wilkinson KD,Miller WE,Lefkowitz RJ. Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2., , (6650-5) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Augustus AM,Reardon PN,Spicer LD. MetJ repressor interactions with DNA probed by in-cell NMR., . Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Ma B,Reynolds CM,Raetz CR. Periplasmic orientation of nascent lipid A in the inner membrane of an Escherichia coli LptA mutant., , (13823-8) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Frederick JP,Tafari AT,Wu SM,Megosh LC,Chiou ST,Irving RP,York JD. A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation., , (11605-12) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Shukla AK,Violin JD,Whalen EJ,Gesty-Palmer D,Shenoy SK,Lefkowitz RJ. Distinct conformational changes in {beta}-arrestin report biased agonism at seven-transmembrane receptors., . Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Beaulieu JM,Marion S,Rodriguiz RM,Medvedev IO,Sotnikova TD,Ghisi V,Wetsel WC,Lefkowitz RJ,Gainetdinov RR,Caron MG. A beta-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior., , (125-36) - Cell Abstract [More ...]

Barb AW,Jiang L,Raetz CR,Zhou P. Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding., . Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Wisler JW,Dewire SM,Whalen EJ,Violin JD,Drake MT,Ahn S,Shenoy SK,Lefkowitz RJ. A unique mechanism of beta-blocker action: Carvedilol stimulates beta-arrestin signaling., . Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Otto JC,Kelly P,Chiou ST,York JD. Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases., . Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Williams AH,Raetz CR. Inaugural Article: Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase., , (13543-50) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Xiao K,McClatchy DB,Shukla AK,Zhao Y,Chen M,Shenoy SK,Yates JR 3rd,Lefkowitz RJ. Functional specialization of {beta}-arrestin interactions revealed by proteomic analysis., . Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Whalen EJ,Foster MW,Matsumoto A,Ozawa K,Violin JD,Que LG,Nelson CD,Benhar M,Keys JR,Rockman HA,Koch WJ,Daaka Y,Lefkowitz RJ,Stamler JS. Regulation of beta-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2., , (511-22) - Cell Abstract [More ...]

Wang X,Ribeiro AA,Guan Z,Abraham SN,Raetz CR. Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase., , (4136-41) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Snyder PW,Lee G,Marszalek PE,Clark RL,Toone EJ. A stochastic, cantilever approach to the evaluation of solution phase thermodynamic quantities., . Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Nelson CD,Perry SJ,Regier DS,Prescott SM,Topham MK,Lefkowitz RJ. Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins., , (663-6) - Science Abstract [More ...]

Warren JJ,Forsberg LJ,Beese LS. The structural basis for the mutagenicity of O6-methyl-guanine lesions., . Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]