Publications

Selected Publications

  1. Chen, W, Kirkbride, K.C., How, T., Nelson, CD, Mo, J., Frederick, JP, Wang, X-F., Lefkowitz, R.J. and Blobe, G.C. β-Arrestin 2 Mediates Internalization of the Type III TGF-β Receptor and Down Regulation of its Signaling. Science 2003; 301:1394-1397. [Full Text] [Related Perspective]
  2. Dong, M., How, T., Kirkbride, K.C., Gordon, K.G., Lee, J.D., Hempel, N., Kelly, P., Moeller, B.J., Hempel, N., Marks, J.R. and Blobe, G.C. The type III TGF-β receptor suppresses breast cancer progression. J. Clin. Inv. 2007; 117:206-17. [Full Text]
  3. Turley, R.S., Finger, E.C., Hempel, N., Fields, T.A. and Blobe, G.C. The type III TGF-β Receptor as a Novel Tumor Suppressor Gene in Prostate Cancer. Cancer Research 2007; 67:1090-1098. [Full Text]
  4. Kirkbride, K.C., Townsend, T.A., Bruinsma, M.W., Barnett, J.V. and Blobe, G.C. Bone Morphogenetic Proteins signal through the Transforming Growth Factor-β Type III receptor. J Biol Chem 2008: 283: 7628-7637. [Full Text]
  5. Mythreye, K. and Blobe, G.C. The type III TGF-β receptor regulates epithelial and cancer cell migration through β-arrestin2-mediated activation of Cdc42. Proc Natl Acad Sci 2009; 106:8221-6. [Full Text]
  6. Swaminathan, V., Mythreye, K., O’Brien, E.T., Berchuck, A., Blobe, G.C.* and Superfine, R.* Mechanical stiffness of cells dictates cytoskeleton dependent cancer cell invasion. Cancer Research 2011; 71:5075-80 *equal contribution. [Full Text]
  7. Tian H, Mythreye K, Golzio C, Katsanis N, Blobe GC. Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells. EMBO J. 2012; 31:3885-900. [Full Text]
  8. Karthikeyan, M., Knelson, E.H., Gatza, C.E., and Blobe GC. TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells. Oncogene. Oncogene 2013; 32:1416-27. [Full Text]
  9. Hanks, B.A., Holtzhausen, A., Evans, K.S., Jamieson, R., Gimpel, P., Campbell, O. M., Hector-Greene, M., Sun, L., Tewari, A., George, A., Starr, M., Nixon, A., Augustine, C., Beasley, G., Tyler, D.S., Osada, T., Morse, M. A., Ling, L., Lyerly, H.K., and Blobe, G.C. Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment. J. Clin. Inv. (2013) 123:3925-40. [Full Text]
  10. Knelson, E.H., Gaviglio, A.L., Tewari, A.K., Armstrong, M.B., Karthikeyan, M. and Blobe, G.C. The Type III TGF-β Receptor Promotes FGF2-mediated Neuronal Differentiation in Neuroblastoma J. Clin. Inv. 2013; 123:4786-98. [Full Text]
  11. Holtzhausen, A., Golzio, C., How, T., Lee, Y.H., Schiemann, W.P., Katsanis, N., Blobe, G.C. Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development. FASEB J. 2014; 28:1248-67. [Full Text]
  12. Knelson, E.H., Gaviglio, A.L., Nee, J, Starr, M., Nixon, A., Marcus, S., and Blobe, G.C. Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth. J. Clin. Inv. 2014; 124:3016-31. [Full Text]
  13. Elderbroom, J.E., Huang, J. Gatza, C.E., How, T., Starr, M., Nixon, A.B. and Blobe, G.C. Ectodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion. Mol Biol Cell (2014). 25:2320-32. [Full Text]
  14. Tian, H., Liu, J., Chen, J., Gatza, M.L.,Blobe, G.C. Fibulin-3 is a Novel TGF-β pathway Inhibitor in the Breast Cancer Microenvironment. Oncogene (2015) 34:5635-5647. [Full Text]
  15. Cribb, J.A., Osborne, L.D., Beicker, K., Psioda, M., Chen, J., O'Brien, E.T., Taylor, R.M., Vicci, L., Hsiao, J.P., Shao, C., Falvo, M., Ibrahim, J.G., Wood, K.C., Blobe, G.C., Superfine, R. An Automated High-throughput Array Microscope for Cancer Cell Mechanics. Sci Rep. (2016) 6:27371. [Full Text]
  16. Gaviglio, A.L., Knelson, E.H., Blobe, G.C. Heparin-binding epidermal growth factor-like growth factor promotes neuroblastoma differentiation. The FASEB J 2017; 31:1903-1915. [Full Text]
  17. Tian, H., Huang, J.J., Golzio, C., Gao, X., Hector-Greene, M, Katsanis, N., Blobe, G.C. Endoglin interacts with VEGFR2 to promote angiogenesis. The FASEB J 2018; 32:2934-2949. [Full Text]
  18. Zhao, F, Evans, K.S., Xiao, C., DeVito, N., Theivanthiran, B., Holtzhausen, A., Blobe, G.C., and Hanks, B. Stromal Fibroblasts Mediate Anti-PD-1 Antibody Resistance via MMP-9 and Dictate TGF-β Inhibitor Therapy Sequencing in Melanoma. Cancer Immunology Research 2018; 6:1459-1471. [Full Text]
  19. Huang, J.J., Corona, A.L, Dunn, B.P., Cai, E.M., Prakken, J.N., and Blobe G.C. Increased type III TGF-β receptor shedding decreases tumorigenesis through induction of epithelial-to-mesenchymal transition. Oncogene 2019; 38:3402-3414. [Full Text]