Scientific Goals

Basic and Clinical Research Program | Scientific Goals

The scientific goals of the program are:

  1. To conduct epidemiological and molecular epidemiological studies to investigate etiology, and to identify populations at greater and lesser risk for development of malignant brain tumors in adults and children;
  2. To determine molecular mechanisms of transformation, altered growth control, and invasion of malignant brain tumors of adults and children;
  3. To identify new drugs active against primary brain tumors of adults and children, to determine mechanisms of drug resistance in primary brain tumors, and to institute methods to overcome drug resistance;
  4. To develop monoclonal antibodies and recombinant DNA antibody fragments reactive with molecular targets, primary brain tumors, and to develop immunoconjugates for brain tumor treatment;
  5. To develop new radiolabeling technology for peptides and monoclonal antibodies and their fragments that will facilitate the invetigation of promising radionuclines, including the α-emitter 211-Astatine, and the beta emitter lutetium 177, in targeted radiotherapy clinical trials for brain tumor patients;
  6. To develop cell-mediated immunotherapy and dendritic-based vaccine trials for brain tumors;
  7. To develop oncolytic poliovirus, with no neurovirulence, but retention of oncolytic capacity for gliomas, into a reagent that can be used for therapy of malignant gliomas and neoplastic meningitis from breast cancer;
  8. To develop imaging capabilities with Positron Emission Tomography (PET) for improved brain tumor diagnosis, monitoring of therapeutic response, and determination of patient-specific radiation dosimetry in radiolabeled antibody, chemotherapy, and
    small molecular inhibitor clinical trials in brain tumor patients;
  9. To design and execute Phase I, Phase II, and Phase III clinical trials in primary and metastatic brain tumors in adults and children, based on laboratory discoveries within the Program, and to execute clinical trials for improvement of quality of life in brain tumor patients.

This article comes from The Preston Robert Tisch Brain Tumor Center at Duke
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